Mesoblast is using its proprietary mesenchymal lineage cell technology platform to develop and commercialize innovative allogeneic cellular medicines to treat complex inflammatory diseases resistant to conventional standard of care. The company is one of several biotech firms aiming to use mesenchymal stem cells as a potential COVID-19 treatment. Commenters are encouraged to use their real names, but anonymous comments are accepted. The basic premise seems to be that remestemcel-L may suppress the overactive immune response of COVID-19 patients, limiting “friendly fire” damage from the immune system and perhaps turning down the cytokine storm of COVID.However, GvHD is a very different disease than COVID-19 or MIS-C. For one thing, in GvHD it is someone else’s immune cells causing the damage, while in COVID-19 it is our own cells that overdo it. The FDA considers them drugs. The funds were provided to Mesoblast under the Government's R&D Tax Incentive Program, designed to support industry innovation.In February 2016, Mesoblast's Licensee (JCR Pharmaceuticals Co., Ltd.) sold its first allogeneic cell product TEMCELL® HS Inj., for the treatment of acute graft versus host disease (aGVHD) in children and adults in Japan. SCOPE has been a big hit and as the number of languages has grown, the number of page views of my white paper “What are stem cells?” in languages besides English has skyrocketed. JR-031 was granted orphan drug priority review. Yeah, they are extremely unusual drugs, but they are drugs. How MSCs Help GvHD. The estimated primary completion date will be February 2019. On April 1, the FDA accepted a priority review filing for use of the treatment against graft-vs-host disease. This intellectual property portfolio covers composition of matter, manufacturing, and therapeutic applications of mesenchymal lineage cells. They express a number of receptors for various inflammatory cytokines, including TNF-alpha receptor, IL-1 receptor, IL-6 receptor, interferon gamma receptor. Too often the info that is out there is either wrong, misleading, or overly complex. In addition, Mesoblast noted that the FDA has provided written guidance that included use of a composite primary endpoint is acceptable for approval, agreed thresholds for pain (50% decrease in VAS) and function (15 point improvement in ODI), two time points (12 and 24 months) for meeting pain and functional improvement criteria and no intervention at the treated level of the spine through 24 months. “Instead of replacing or fusing the disc, there is mounting compelling evidence that we can use this regenerative medicine to heal the disc. I know there are thousands of people out there looking for more practical information about stem cell therapies and treatments. Mesoblast’s remestemcel-L treatment is derived from allogenic mesenchymal stem cells, which when infused into the body can slow down an immune response and prevent the body from damaging itself. I have to wonder if the steroids alone might do enough on their own for some patients remestemcel-L and other MSC approaches could also have risks for these COVID pediatric patients. "In May 2017, Mesoblast noted in the 3rd Quarter report that they target patient enrollment completion of the Phase 3 back pain trial by the end of 2017. One of the diseases the company has been working to treat is graft-vs-host disease, a condition that arises in patients who receive bone marrow transplants. http://twitter.com/pknoepfler I’ve also done some of the work for you and have links to stem cell clinic trial listings below for specific diseases. Our motto could be articulated as “Not lost in translation!” Stem cells are a topic that concerns the people of the world, not just certain countries or certain people speaking only in certain languages.

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